Thursday, January 31, 2008

Gene Predicts Heart Attack Response And Cardiac Damage

A recently discovered protein found to influence the response of the heart to a lack of oxygen and blood flow, may present a new therapeutic approach to treating these conditions associated with heart attack. The protein is called macrophage migration inhibitory factor (MIF), and it was found to activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance, which protects the heart from injury during a heart attack. They found that when MIF is released in response to a lack of oxygen, it leads to the activation of AMPK, resulting in a protective metabolic effect in the heart. When researchers, tested rats lacking the MIF gene, they found them to have a deficiant AMPK response, and they suffered more severe heart attacks than mice with an intact MIF gene. This study suggests that we may be able to identify individuals, based on their genetic characteristics, who are likely to suffer more cardiac damage during a heart attack.

http://www.sciencedaily.com/releases/2008/01/080130141616.htm

Wednesday, January 30, 2008

Stem Cell Treatment For Brittle Bones In The Womb

Osteogenesis imperfecta (also called Brittle Bone Disease) is a genetic bone disorder. In osteogenesis imperfecta (OI), collagen, the building block for bones, fails to develop properly. Therefore, this leads to the condition of having brittle bones and may cause fractures during childhood and even in the womb. Fortunately, scientists at the Action Medical Research have announced a breakthrough where a stem cell treatment is possible for embryos with brittle bones. The breakthrough originated from a group of scientists that transplanted stem cells from the fetus blood into two-week old mice fetuses. After experimentations, the researchers discovered a decrease in bone fractures by two thirds within the treated mice compared with untreated group of mice. This study suggests that we can apply the same method to humans. Not only can this breakthrough help patients with OI but also patients diagnosed with other diseases such as muscular dystrophy. I think this discovery is fascinating because it shows that if stem cells could be transplanted in a baby in the womb, this could lead to a great improvement in the baby’s health.

http://www.sciencedaily.com/releases/2008/01/080129125455.htm

Tuesday, January 29, 2008

Sedentary life 'speeds up ageing'

A recent study of over 1,000 twins found those who were active during their leisure time appeared biologically younger than their sedentary peers. Subjects whose weekly exercise was as low as 16 minutes per week had an average telomere length of 200 nucleotides less than those with the most physical activity per week, around 199 minutes. Telomeres, the repeat sequences of DNA that sit on the ends of chromosomes, are essential for protecting genes from damage. Most active people had telomere length comparable to those of sedentary people who were 10 years younger.

http://news.bbc.co.uk/2/hi/health/7212698.stm

Monday, January 28, 2008

A robot performing cardiac surgery?

There are two types of robotic surgery technologies which have recently been introduced to hospitals for catheter insertion and treatment of arrhythmia - the Sensei Robotic Catheter System by Hansen Medical and the Stereotaxis system. These systems are equipped with a joystick that the cardiologist uses to advance and maneuver a catheter, guided by 3-D images generated fluoroscopically. In the case of the Stereotaxis system, the catheter is guided by a magnetic navigation system.



Hansen Medical System




Stereotaxis System

Both robotic systems boast that they are more accurate and precise, as well as offer more steady "hands" to control the catheter, than strictly human guided catheter insertion. These devices are used to treat arrhythmia by ablating specific areas of the heart to alter the paths taken by the electrical currents that cause cardiac muscle contractions, and thereby alter the way the heart beats, hopefully for the better.

The Hansen system was just approved by the Food and Drug Administration last year, and is currently used in seven hospitals in the US, while the Stereotaxis system has been on the market for more than two years.

http://www.statesman.com/search/content/news/stories/local/01/27/0127robot.html
http://www.hansenmedical.com/products/default.aspx
http://www.stereotaxis.com/Products-Technology/

Eyeing up a new Technology

CONVENTIONAL contact lenses are good at correcting vision. That, however, is not enough for Babak Parviz. Dr Parviz, who works at the University of Washington, in Seattle, wants to get them to provide information, too. His model is the “head-up” displays on the windscreens of aircraft that are also becoming popular in cars. Shrinking the technology used in these applications to the point where it can be employed in tiny, flexible lenses has proved challenging. But last week, at a conference in Tucson, Arizona, organised by the Institute of Electrical and Electronics Engineers, Dr Parviz announced that he was getting close.
The lenses themselves are made out of polyethylene terephthalate (PET), a substance similar to that used in overhead projection sheets. Dr Parviz uses PET because his previous research has shown that metal circuits can be safely and effectively attached to it. The trick is building that circuitry in the first place, because the components—most notably, light-emitting diodes, or LEDs—have to be manufactured at high temperatures using processes that involve corrosive liquids.
The usual trick of doing this in situ on a piece of silicon that also serves as the circuit board would not work on a piece of PET, which would be destroyed almost instantly. Instead, Dr Parviz employs a technique he developed the year before last, and for which this is the first practical use.
It works by etching small, precisely shaped holes in the PET. The shapes of the holes match those of particular components. Those components are manufactured elsewhere, using the traditional, plastic-hostile techniques. They are then mixed together to create a grey powder that is floated in alcohol over the surface of the lens.
When a component floats over an appropriately shaped hole in the PET, it slips into position. In this way, not only can LEDs be laid down, but also tiny solar panels and antennae that convert radio waves into electrical energy. Everything is thus in place for a display unit that can extract power from the outside world, and also receive signals from it. All that need then be done is to encapsulate the result in Perspex (chosen because, being the material from which hard contact lenses are routinely made, it can protect the circuitry with harming the wearer’s eye) and shape the whole thing on a heated aluminium mould, so that it fits the eyeball of the wearer.
At the moment, Dr Parviz’s prototype does not produce a useful image. That would require much more complicated circuitry than he has built so far. But he can make the LEDs flash on and off, so the principle seems to work. The next stage is to get someone to try one of the lenses on. That, in today’s risk-averse world, requires regulatory approval. But even by getting his self-assembled screen of LEDs to flash, Dr Parviz has shown that circuits can be built at room temperature this way. And that, rather than the specifics of this particular bionic eye lens, is the real point of the exercise.
http://www.economist.com/displaystory.cfm?story_id=10557698
Laura Hernandez-Cruz

Sunday, January 27, 2008

NIH Launches Human Microbiome Project

The NIH began funding the Human Microbiome Project, a project dedicated to analyzing foreign microorganisms in the human body. It is known that microorganisms roughly account for two pounds of weight it a grown adult, and they might outnumber the number of human cells, but little is known about their role in human functioning and pathology. A good balance of these organisms are maintained in a healthy human being, but overproliferation of these organisms are implicated in several diseases, including diabetes, final stages of AIDS, asthema, and mortality with burn victims.

The project will begin with sequencing the genomes of these organisms, and then taking samples from diseased and non-diseased patients. Accordingly, the first four centers to receive funding were sequencing centers. The NIH hopes to eventually spend $115 million on the project.

I find the article interesting because I had no idea that these microorganisms could outnumber the number of my own cells in my body. It is sort of unsettling that the majority of me is not, well, me. At the same time, the human body is the perfect breeding ground for bacteria, and the immune system can not be expected to eliminate every single "non-self" it encounters.

http://www.nih.gov/news/pr/dec2007/od-19.htm

Saturday, January 26, 2008

Is This The Beginnings of Artificial Life?

Scientists in America have found a way to replicate a bacterium's 582,970 base pair genome, which is the largest man-made DNA structure ever made. This opens up the possibility to produce fuel from these "man-made" bacteria.

Scientists say that these synthetic versions of micro-organisms, made from chemically synthesized DNA blocks that have been woven together, can be designed to produce hydrogen or absorb carbon dioxide in the air. The J Craig Venter Institute says that there is one final step to creating a fully synthetic organism: to create a living bacterial cell based completely on the synthetic genome. Making this genome was a huge challenge and the scientists consider it to be an enormous accomplishment towards making the creation of biofuels possible.


http://www.medicalnewstoday.com/articles/95219.php

Tuesday, January 22, 2008

Genes Increase Prostate Cancer Risk

Researchers have recently discovered a series of gene markers that when in the presence of family history of prostate cancer increase the risk of over 900%. According to researchers, these markers can easily be identified in a blood or saliva sample. The new genetic test complements the current methods that rely on physical symptoms, age, race, family history, and PSA screens.

Though the test will help patients identify the disease more accurately and quickly, it does not show who is at risk for developing the aggressive form of prostate cancer. The research is currently underway in trying to identify this form. Not every man is at high risk of prostate cancer, but for the few who are have hope that they will be able to identify the cancer early enough with the help of these gene markers.

http://www.time.com/time/health/article/0,8599,1704160,00.html

Monday, January 21, 2008

From And For The Heart, My Dear Valentine: Broccoli

So mama was right when she told us to eat our broccoli! Research has shown that broccoli may contain nutrients that lead to a healthier heart. Broccoli has been known to help reduce the risks of cancer because it contains antioxidants, vitamins, and fiber. With this new information about broccoli it could become a POWER vegetable in the fight against disease.

A new study using lab rats supports this new information about broccoli and the heart. In the study broccoli extract was given to a group of rats for one month. When compared to the control group of rats, the broccoli fed rats had improved heart function. In a part of the experiment the rats were given less oxygen than normal; the group of rats that been fed broccoli had less heart muscle damage. Researchers believe that the effects from the broccoli are from its high concentrations of substances that increase levels of thioredoxin. Thioredoxin is a protein that protects the heart.

So for this Valentine's Day don't forget to get that special someone some BROCCOLI!



http://www.sciencedaily.com/releases/2008/01/080121091349.htm

Tuesday, January 15, 2008

Biotechnology Builds a New Heart


Researchers at the University of Minnesota Center for Cardiovascular Repair have successfully created a beating heart using the outer structure of one heart and injecting heart cells from another rat. The technique, called whole organ decellularization, could be used in a similar process to create a replacement heart for humans in need of a heart transplant.

The scientists first used detergents and other chemicals to wash out all the old heart cells from rat and pig hearts, leaving a scaffold of tubes that once were the organ’s blood vessels. Stem cells were then injected into the scaffold, where they were supplied with nutrients, allowing them to grow and create a new organ. Within eight days, the hearts were effectively pumping.

This new research is exciting because the stem cells from a recipient’s body could be used to regenerate a heart. This means that the heart would be immunologically similar to the recipient making the body less likely to reject it.

Nearly 5 million people in the United States suffer from heart failure and approximately 50,000 of those patients die each year awaiting a donor heart.