Neovascularization of Synthetic Membranes Directed by Membrane Microarchitecture
http://www.ncbi.nlm.nih.gov/pubmed/8600142
In this study, the porosity of a polytetrafluoroethylene (PTFE) membrane was varied to study the correlation between porosity and vascular growth. It was found that larger pores had 80-100 fold more vascular structures. This type of investigation is a key aspect of preventing immune rejection of tissue transplantation devices. In general, the inflammatory reaction may be attributed to the primary adhesion of a layer of immune cells, the secondary avascular region, and a tertiary vascularized region surrounding the device membrane. The use of such large pore sizes, to induce vascularization, and a laminate to create a smaller pore inner membrane and thus prevent cell entry into the device is ideal for minimization of the inflammatory response.
This study is interesting in that the micro-architecture of the membrane is able to influence the behavior of inflammatory cells. If such a postulate is true universally, it holds that the structure of an engineered matrix itself is able to affect cell behavior. This is a discovery that may have implications in various aspects of the development of membranous devices, tissue scaffold constructs, and other devices that must be protected from immune rejection.
In this study, the porosity of a polytetrafluoroethylene (PTFE) membrane was varied to study the correlation between porosity and vascular growth. It was found that larger pores had 80-100 fold more vascular structures. This type of investigation is a key aspect of preventing immune rejection of tissue transplantation devices. In general, the inflammatory reaction may be attributed to the primary adhesion of a layer of immune cells, the secondary avascular region, and a tertiary vascularized region surrounding the device membrane. The use of such large pore sizes, to induce vascularization, and a laminate to create a smaller pore inner membrane and thus prevent cell entry into the device is ideal for minimization of the inflammatory response.
This study is interesting in that the micro-architecture of the membrane is able to influence the behavior of inflammatory cells. If such a postulate is true universally, it holds that the structure of an engineered matrix itself is able to affect cell behavior. This is a discovery that may have implications in various aspects of the development of membranous devices, tissue scaffold constructs, and other devices that must be protected from immune rejection.
posted by Unknown at 9:19 PM
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