The Effects of Pore Size in Bilyared Poly(lactide-co-glycolide) Scaffolds on Restoring Osteochondral Defects in Rabbits
http://www.ncbi.nlm.nih.gov/pubmed/23637068
In repairing osteochondral defects, it is important to consider pore size as a determinant of cell proliferation and ultimate tissue growth. Bi-layered scaffolds are especially attractive to regeneration of injury to the osteochondral interface due to its enhanced ability to better mimic both articular cartilage and subchondral bone. In this study, bi-layered porous scaffolds were fabricated, in which only porosity was modulated in each layer, and implanted into the medial condyle of rabbits. Duan et al found that pore sizes ranging from 100-200 microns in the chondral layer, and 300-450 microns in the osseus layer generated the best results- better overall tissue regeneration and integration with the graft site.
This aspect of biomedical engineering, that is, investigating the effects of scaffold properties on cell behavior, is an important aspect in the development of novel regenerative techniques. Rather than using other therapies such as micropicking and osteochondral autograft transfer systems which have variable success, the use of an engineered scaffold seeded with autologous cells holds great promise as a more viable treatment of tissue degeneration.
In repairing osteochondral defects, it is important to consider pore size as a determinant of cell proliferation and ultimate tissue growth. Bi-layered scaffolds are especially attractive to regeneration of injury to the osteochondral interface due to its enhanced ability to better mimic both articular cartilage and subchondral bone. In this study, bi-layered porous scaffolds were fabricated, in which only porosity was modulated in each layer, and implanted into the medial condyle of rabbits. Duan et al found that pore sizes ranging from 100-200 microns in the chondral layer, and 300-450 microns in the osseus layer generated the best results- better overall tissue regeneration and integration with the graft site.
This aspect of biomedical engineering, that is, investigating the effects of scaffold properties on cell behavior, is an important aspect in the development of novel regenerative techniques. Rather than using other therapies such as micropicking and osteochondral autograft transfer systems which have variable success, the use of an engineered scaffold seeded with autologous cells holds great promise as a more viable treatment of tissue degeneration.
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