Master Regulator of Skin Development Discovered
http://www.sciencedaily.com/releases/2012/12/121202164434.htm
A new molecule, TINCR, is required to direct precursor molecules to help them in their processes of differentiation. It binds and stabilizes differentiation genetic messages, mRNA. Blocking this activity stops differentiation of skin cells. TINCR is however not a protein, but it is a relatively new class of regulatory molecules called non-coding RNAs or IncRNAs. They do not carry instructions the instructions to make proteins. They are longer than microRNAs. It stabilizes certain mRNA transcripts and it can perfect gene expression. These researchers looked at RNAs that are more expressed in keratinocytes than progenitor cells. TINCR levels of expression were 150 times greater. Researchers developed two assays: one for identifying interactions in RNA molecules, and another to suss out interactions between a regulatory RNA and its corresponding protein. Another approach involves a microarray with over 9400 different proteins. These proteins were exposed to TINCR and STAU1 bound strongly to TINCR.
I think this article is pretty cool considering they are pinpointing RNA molecules that will be able in the far future be able to help with skin grafting or to make other types of cells. Starting with this small molecule and its role in epidermal cell differentiation could change the way of stem cell research in humans. These RNA molecules can code for proteins that can help repair skin in whatever type of situation and it gives hope to people with damaged skin such as a burn victim. This differentiation non-regulatory RNA gives sight into how much we are still learning and discovering about the genome and gives hope in the fact that we might finally pinpoint other genes to help with other disease or differentiation.
A new molecule, TINCR, is required to direct precursor molecules to help them in their processes of differentiation. It binds and stabilizes differentiation genetic messages, mRNA. Blocking this activity stops differentiation of skin cells. TINCR is however not a protein, but it is a relatively new class of regulatory molecules called non-coding RNAs or IncRNAs. They do not carry instructions the instructions to make proteins. They are longer than microRNAs. It stabilizes certain mRNA transcripts and it can perfect gene expression. These researchers looked at RNAs that are more expressed in keratinocytes than progenitor cells. TINCR levels of expression were 150 times greater. Researchers developed two assays: one for identifying interactions in RNA molecules, and another to suss out interactions between a regulatory RNA and its corresponding protein. Another approach involves a microarray with over 9400 different proteins. These proteins were exposed to TINCR and STAU1 bound strongly to TINCR.
I think this article is pretty cool considering they are pinpointing RNA molecules that will be able in the far future be able to help with skin grafting or to make other types of cells. Starting with this small molecule and its role in epidermal cell differentiation could change the way of stem cell research in humans. These RNA molecules can code for proteins that can help repair skin in whatever type of situation and it gives hope to people with damaged skin such as a burn victim. This differentiation non-regulatory RNA gives sight into how much we are still learning and discovering about the genome and gives hope in the fact that we might finally pinpoint other genes to help with other disease or differentiation.
posted by Anonymous at 9:00 AM
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