A new nano-technique was used along with scanning ion conductance microscopy (SICM) in order to study the minute details of the heart cells and the connection to heart failure. Chemical probes were inserted that fluoresce when certain beta-receptors are active in the heart tissue. Using this form of microscopy, researchers were able to see the surface of the cells and even observe the state of the t-tubules, which isn’t possible using other forms of microscopy.

It was discovered that when the cells are damaged, certain beta-receptors, located by the t-tubules, that usually protect the cell move towards a more degenerative form of beta receptor and have a decreased ability to protect the cell. This discovery could lead to improved beta-receptor blocking drugs, which is the normal treatment at the moment. Being able to only block the degenerative forms of a beta-receptor, while leaving the protective receptors could lead to prolonged life and decrease a need for transplants in the near future.

I found this really interesting because it combines aspects that we have talked about in class this semester with concepts from last semester. This is just another example of how nano technology is immediately improving the health industry by creating new methods and techniques. I also found it interesting that in the long term, beta receptors, which are influenced by the sympathetic nervous system, can be potentially inducing cell damage. Of course, when healthy, the body counteracts this with receptors that have protective properties, limiting these negative effects.

http://www.sciencedaily.com/releases/2010/02/100225142449.htm