Monday, May 01, 2006

Cancer Drugs treat HGPS?

Hutchinson-Gilford progeria syndrome (HGPS) is a genetic condition is known to cause what looks like premature aging. Stephen Young from UCLA reports that a drug developed to treat cancer can delay symptoms and increase the survival of mice with a similar disease. In HGPS, mutation occurs in the gene encoding precursor of lamin A. This provides the membrane of the nucleus its structure. Another enzyme called ZMPSTE24 cleaves the protein to produce mature lamin A. When the cleavage site is altered, it leads to buildup and mutation of prelamin A. Research on farnesyltransferase inhibitors (FTIs), which help treat cancer, was tested on mice to restore nuclei back to their normal shape which looks like a promising research!
http://www.sciencemag.org/cgi/reprint/311/5763/934a.pdf

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