Function Tissue Made From Stem Cells
Dr. Snoeck of the Columbia
Center for Translational Immunology was able to differentiate stem cells into
lung cells. This has many significant results, one being the ability for
researches to study how lung diseases originate in hopes of better treatment options.
These results are beneficial in that 90% of the time, the cells of lung
transplant recipients reject the donated organ, and also, the 10 year survival
rate for the recipients is only 28%.
Snoeck did so by converting stem cells into the precursor endoderm
cells that then would differentiate into six different respiratory tissues. One
of those six includes type 2 alveolar cells that allows the lungs to maintain
with air, and also aids with gas exchange. These methods also leave
possibilities for patients to regrow a disease-free lung, thereby eliminating
the need to wait on a transplant list as well as the risk for rejection of a
transplant. In this situation, scientists would remove and decellularize the
patient’s lung, coat it with stem cells, and place the organ back into the
patient after the regrowth of tissue.
Columbia University has filed a patent for whatever their
specific technique is to retain these results, but it is still under research.
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