Apoptosis of HIV virus (PLOSONE)
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0074414;jsessionid=B91111EA9FA2C951C8BA972F703EFAA5
Apoptosis, as we all know by now is the programmed cell death, and diseases such as HIV avoid this natural phenomena which is one of the reasons why HIV is very difficult to eradicate. Now a days, scientists claim that apoptosis can be induced in the HIV virus by "interfering" with the HIV-1 gene expression. Commonly used chemicals such as the topical anti fungal, ciclopirox and the iron chelator, deferiprone affect apoptosis in HIV infected H9 cells. Both medicines activated apoptosis in HIV infected cells in the body, which will slow down HIV spreading further. Both medicines enhanced the mitochondrial membrane depolarization which initiates the intrinsic pathway that induces apoptosis. Caspase-3 activation, poly(ADP-ribose) polymerase proteolysis, DNA degradation, and apoptotic cell morphology are evidence that apoptosis is induced and is executed. Also, no viral re-emergence was observed 12 weeks after the drug was done being administered which is evidence that the virus was eliminated from the host's DNA. Tests in mice given the ciclopirox didn't show any tissue damage. The results of many experiments showed that the mice given either the ciclopirox or the deferiprone had preferential treatment in the way they induced apoptosis in the cells, The hosts given the medications caused apoptosis to occur in the HIV infected cells first. Scientists hypothesize that the drugs act as anti-retrovirals due to the fact that they inhibit hydroxylation of cellular proteins heavily involved apoptosis. Scientists are also claiming that these drugs are cytocidal due to the fact that they eliminate viral activity by destroying infected cells. I believe that this is a very effective, pragmatic way to limit the spread of HIV due to the fact that HIV is constantly changing its outer proteins which makes it very hard to track down and eliminate, and is definitely worth test trials in humans.
Apoptosis, as we all know by now is the programmed cell death, and diseases such as HIV avoid this natural phenomena which is one of the reasons why HIV is very difficult to eradicate. Now a days, scientists claim that apoptosis can be induced in the HIV virus by "interfering" with the HIV-1 gene expression. Commonly used chemicals such as the topical anti fungal, ciclopirox and the iron chelator, deferiprone affect apoptosis in HIV infected H9 cells. Both medicines activated apoptosis in HIV infected cells in the body, which will slow down HIV spreading further. Both medicines enhanced the mitochondrial membrane depolarization which initiates the intrinsic pathway that induces apoptosis. Caspase-3 activation, poly(ADP-ribose) polymerase proteolysis, DNA degradation, and apoptotic cell morphology are evidence that apoptosis is induced and is executed. Also, no viral re-emergence was observed 12 weeks after the drug was done being administered which is evidence that the virus was eliminated from the host's DNA. Tests in mice given the ciclopirox didn't show any tissue damage. The results of many experiments showed that the mice given either the ciclopirox or the deferiprone had preferential treatment in the way they induced apoptosis in the cells, The hosts given the medications caused apoptosis to occur in the HIV infected cells first. Scientists hypothesize that the drugs act as anti-retrovirals due to the fact that they inhibit hydroxylation of cellular proteins heavily involved apoptosis. Scientists are also claiming that these drugs are cytocidal due to the fact that they eliminate viral activity by destroying infected cells. I believe that this is a very effective, pragmatic way to limit the spread of HIV due to the fact that HIV is constantly changing its outer proteins which makes it very hard to track down and eliminate, and is definitely worth test trials in humans.
posted by Nema Bassiri at 8:04 PM
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