Probiotics in Traumatic Brain Injury

While working on the nanobot project, all of the proposed designs and solutions were extremely interesting, and seemed like they could all be viable methods with a little bit of tweaking. However, there was one practical problem with every design and that they all rely on future technology. I was interested in some of the current methods and their effectiveness.

Tramautic brain injury has been associated with a shift from T helper 1 to T helper 2 immunological response. It was hypothesized that a readjustment of this imbalance would improve clinical outcomes in TBI patients. This imbalanced would be adjusted by enteral admission of probiotics.

In the study, 26 patients were given probiotics, and 26 were placed in the control group, and a variety of different factors were monitered. These included serum levels of Th1/Th2 cytokines, length of ICU stay, and 28-day mortality rate. At the end of the trial period the study showed decreased ICU stays and less nosocomial infections in the group recieving probiotics. The altered Th1/Th2 response was also attenuated, which resulted in the i9mprovements of clinical treatment. Hoever, the 28-day mortality rate was not affected.

Thus, right now treatment is being done to greatly improve patient care of brain trauma patients, and is an effective way to at least reduce infections by enhancing immunological status.

http://ccforum.com/content/pdf/cc10579