'Retina in a Dish' is the Most Complex Tissue Ever Engineered in the Lab

Researchers in Japan have recently succeeded in growing a retina from mouse embryonic stem cells in a lab. This is allegedly the most complex biological tissue yet engineered. The cross-over into human transplantation could provide a useful resource for studying many diseases that cause blindness with the goal of eventually providing retinal implants to qualified patients.The actual tissue developed at Kobe's RIKEN Center for Developmental Biology is a two-layered organ that is composed of both the retina and an outer layer of pigmented cells that provide nutrients and support the retina and the light-sensitive cells that are responsible for signal and information conduction to the brain. This feat was primarily achieved through the use of mouse embryonic stem cells in nutrients and a protein gel to protect the developing structure. Though the retina's functionality hasn't yet been tested in live mice, the next phase of research plans to test this. Eventually, the jump to human retinal growth and transplantation could be bridged seamlessly to better the lives of many.

This article was of interest to me since I am interested in pursuing the biomaterials and tissue engineering track of biomedical engineering. Such successful projects as the retina created in this article provide many opportunities for growth in the industry in order to provide a better quality of living for those afflicted with retinal diseases. With steadying progression and devotion in the field of research and development for vital tissues, eventual implantation into human candidates can and will change the face of medicine for the better for many years to come.

Andrew Wagner

VTPP 435-502

http://www.popsci.com/science/article/2011-04/retina-dish-most-complex-tissue-ever-engineered-lab