Placental Precursor Stem Cells Require Testosterone-Free Environment To Survive

Trophoblast stem cells (TSCs), which are found in the peripheral embryonic stem cells, are thought to have an immune system that can fight off many diseases and survive through many infections in order to be transplanted. It has also been shown that the lack of male hormones allow extended transplanted cell survivability. When transplanting cells, it has also been found that it is not required to only transfer to a uterus. Many other organs and tissues of the body can also except these cells, but from research, it has been shown that women are more prone to accepting these cells than men. Although, this research was done on mice. "This was not unexpected, given the natural uterine environment for TSCs," said Dr. Binas. "However, castration of the male mice abolished the sex hormone difference and the livers of the castrated male mice provided a perfect environment for the TSCs." With this experiment, it goes to show that testosterone has some effect on the survival or death of the cells. The document goes on to say how TSC cells become toxic when entered into a male system. That is why the cells do not survive in their living conditions. This study, for the first time, demonstrates that long term survival of trophoblast cells in the absence of ovarian hormones is possible. It is also possible for these cells to survive along with other cells and give them a chance of surviving by living off of each other.

This research study shows that cell transplant is a possible phenomenon. For the fact that TSC cells can be transplanted into another person to reproduce, into other tissues to help survive, and work along with another type of cell to promote its well being is astonishing. The greatest downfall to this aspect is that males producing testosterone do not apply. The cells become toxic and die. On the other hand, women can benefit from this discovery.


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