Nine New X Chromosome Genes Linked to Learning Disability

A team of more than 70 researchers across the globe studied 720 of the 800 known X chromosome genes of 208 families with learning disabilities; the largest screen of this type ever reported. What they found was interesting; that nine genes coded on the X chromosome, when knocked out, lead to learning disabilities. Also, the researchers found that 1 to 2 percent of X chromosome genes, when knocked out, have apparently zero effect on the individual’s ability to learn and function in the ordinary world. This demonstrates the challenges that researchers face with carrying out this type of study; researchers must be cautious about assuming that the presence of a knocked out gene in an individual with a particular disease means that the knocked out gene is causing the disease. The nine genes on the X chromosome linked to learning disability also play roles in a wide range of biological processes, suggesting that disruption to many cellular machines can damage the nervous system; yet another challenge that scientists face. Scientists admit that there may be more genes on the X chromosome that result in learning disabilities, but the these new findings offer great potential for identifying possible learning disabilities in children, and educating parents on whether or not they want to conceive.

http://www.sciencedaily.com/releases/2009/04/090419133841.htm