Spun-sugar Fibers Spawn Sweet Technique For Nerve Repair

Research in Purdue University's biomedical engineering department is leading to developments in nerve regeneration by the use of "spun-sugar" filaments. The research team proposes that tiny synthetic tubes can promote nerve regrowth if used as channels for connecting the ends of damaged or injured nerves. The study focuses on reparing peripheral nerves and possibly restoring damaged blood vessels that have experienced trauma.

In the process of fabricating artificial fibers for nerve regeneration, spun-sugar filaments made of sucrose are coated with a corn-based polymer called poly L-lactic acid. They are then submersed in water causing the sugar to melt and leaving behind small bundles of tubes similar to those in nerves. When the tubes are assembled, Schwann cells are grown on the tubes and align lengthwise to expedite the nerve growth process.

In lab testing, nerves successfully grew inside and outside of the tubes, creating a large surface area, thus promoting regeneration. The results also showed that the tubes were sufficient in supplying nutrients to the growing nerve cells and removing waste. In contrast to the autograft, in which healthy nerves are taken from one area to mend damaged nerve portions in another area, this treatment requires less collateral damage.

With these new discoveries, researchers are hoping to develop a treatment that is more effective, as well as cost efficient.

http://www.sciencedaily.com/releases/2009/02/090226153112.htm

Acacia Ho

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