New Type II Diabetes Genetic Risk Factors
Several Research Institutions teamed together in order to investigate new risk factors for type II diabetes. The research turned up 10 new genetic factors linked to an increased incidence in type II diabetes.
The research was performed using a technique called genome-wide association. A large group of people with type II diabetes were compared to an identical set of people only without the disease. A full DNA study was done and the differences were observed in the genome. Four new variations were found near the following:
GF2BP2. This gene codes for a protein called insulin-like growth factor 2 mRNA binding protein 2. This protein is thought to regulate insulin.
-- CDKAL1. This gene codes for a protein called CDK5 regulatory subunit associated protein1-like1. Cyclin dependent kinase 5 (CDK5) protein, which stimulates insulin production and may influence other processes in the pancreas's insulin-producing cells, could also be affected. In addition, excessive activity of CDK5 in the pancreas may lead to the degeneration of cells.
-- CDKN2A and CDKN2B. The proteins produced by these two genes inhibit the activity of cyclin-dependent protein kinases, including one that has been shown to influence the growth of beta cells.
-- Chromosome 11. More work is needed to determine the exact relationships to pathways involved in type 2 diabetes.
These new genetic factors are a step in the right direction for finding a more permanent cure or prevention for diabetes. The full article can be found here.
http://www.medicalnewstoday.com/medicalnews.php?newsid=69271
The research was performed using a technique called genome-wide association. A large group of people with type II diabetes were compared to an identical set of people only without the disease. A full DNA study was done and the differences were observed in the genome. Four new variations were found near the following:
GF2BP2. This gene codes for a protein called insulin-like growth factor 2 mRNA binding protein 2. This protein is thought to regulate insulin.
-- CDKAL1. This gene codes for a protein called CDK5 regulatory subunit associated protein1-like1. Cyclin dependent kinase 5 (CDK5) protein, which stimulates insulin production and may influence other processes in the pancreas's insulin-producing cells, could also be affected. In addition, excessive activity of CDK5 in the pancreas may lead to the degeneration of cells.
-- CDKN2A and CDKN2B. The proteins produced by these two genes inhibit the activity of cyclin-dependent protein kinases, including one that has been shown to influence the growth of beta cells.
-- Chromosome 11. More work is needed to determine the exact relationships to pathways involved in type 2 diabetes.
These new genetic factors are a step in the right direction for finding a more permanent cure or prevention for diabetes. The full article can be found here.
http://www.medicalnewstoday.com/medicalnews.php?newsid=69271
posted by Andrew Webster at 3:12 PM
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