Celebrex, Among Other Things

Scientists have found four genes that seem to affect breast cancer's ability to metastasize in the lungs. The four genes are COX-2, EREG, MMP-1, and MMP-2. While blocking these genes individually has a small effect on the cancer's ability to metastasize, blocking all four simultaneously gives dramatic results -- even going so far as to nearly entirely eliminate metastasis. Of course, the ability to block these four genes would be incredibly beneficial, since when cancer metastasizes it becomes especially dangerous and truly difficult to treat.

There are a couple of drugs currently on the market that have already been noticed to promote resistance to cancer metastasis, Celebrex being the most well-known. It has been found that these drugs promote this resistance by inhibiting one of the above genes. Therefore, a drug combination that individually inhibits each one of above genes could prove to be a powerful tool in cancer treatment.


http://news.yahoo.com/s/nm/20070411/sc_nm/
cancer_genes_dc;_ylt=AqH3ks4x0__XB1768.s_ru0PLBIF