New role found in toxin-binding protein

Researchers at the University of Wisconsin - Madison found that the toxin-binding protein AHR not only recognizes industrial pollutants, it also helps maintain cardiovascular health. The protein recognizes toxic forms of cholesterol-carrying molecules in the blood and takes steps to eliminate them. In blood vessel linings, it recognizes the misfolded form of LDL. High levels of LDL can lead to atherosclerosis.

The researchers also explain what the source of the misfolded LDL can be - high levels of fluid shear stress. As the LDL travels roughly through the blood vessels, its shape and function can change. The researchers also note that the maligned carrier molecules can cause their own destruction by activating AHR signaling.

Another important note the researchers make is that moderation of this protective mechanism is the key, since high levels of AHR activity can be linked to serious health probelms like cancer and immune suppression.

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