New Calcium-Sensing MRI Contrast Agent

A researcher at MIT has developed a new calcium-sensitive MRI contrast agent that will improve the ability to observe brain function. Current functional MRI machines measure brain function by detecting blood flow through regions of the brain stimulated by electrical waves. This technique has its limitations because once the neurons fire, the change in bloodflow takes several seconds to occur, thus precise activity is not measured. A calcium sensitive MRI agent is a better alternative because it will enter the neurons almost immediately after they are fired. Therefore, increased calcium levels can be tracked as information actually flows through the circuitry of the brain. The designer is using what are called "superparamagnetic nanoparticles" as the sensor for the agent. These particles are molecule sized and can produce higher-resolution images of the brain, than their blood imaging counterparts. This new technique will help in studying the circuitry of the brain.

http://web.mit.edu/newsoffice/2006/imaging-neurons.html


I found this article appealing because it demonstrates how nanotechnology is being used to improve the functionality of MRI scanners. My device team is studying Alzheimer's disease. This new technique will improve the ability to study the brain and neurodegenerative diseases like Alzheimer's.

http://web.mit.edu/newsoffice/2006/imaging-neurons.html