Leaps and Bounds, and meet w/ you Dr. Wasser?
Today (monday) the Saturn 501 group met after a long hiatus for testing periods. When we came together today we had loose ideas but nothing too solid. Today we managed to make the primary design with only a few holes in planning still to work out.
For the delievery into the cell, we will use the macrophage's own function to consume a certain particle which i am hesitant to describe in further detail here. Suffice to say the nano-machine will be inside the particle and will then presumably be delivered to the lysosome. As the lys begins to act on the 'carrier' and it's integrity is ruptured, base, which will be inside along with the nanomachine, will be released to neutralize the acidity of the lysosome. The nano machine will probably have some sort of sheath that wants to be inside the lipid bilayer, thus by a mechanism somewhat too difficult and underdeveloped to described here yet, the nanomachine should be excreted into the cytoplasm.
From here it will undergo its main functioning. there will be a voltmeter which will be described in detail later, which will tell the machine whether to raise or lower the potential difference. Then the machine will take in K+ particles in order to raise the difference, which we will probably assume is the initial problem, and from then on, it will have a store of k+ to release if the difference needs to be lowered, and more room to take more k+ should the difference be higher.
We have more detail here, but time, space, and confidentiality prevent me from describing more.
Incidently, Dr. Wasser, we would like to meet with you this Wednesday sometime, preferably after the lab in the afternoon, but possibly after class, whichever is better for you.
For the delievery into the cell, we will use the macrophage's own function to consume a certain particle which i am hesitant to describe in further detail here. Suffice to say the nano-machine will be inside the particle and will then presumably be delivered to the lysosome. As the lys begins to act on the 'carrier' and it's integrity is ruptured, base, which will be inside along with the nanomachine, will be released to neutralize the acidity of the lysosome. The nano machine will probably have some sort of sheath that wants to be inside the lipid bilayer, thus by a mechanism somewhat too difficult and underdeveloped to described here yet, the nanomachine should be excreted into the cytoplasm.
From here it will undergo its main functioning. there will be a voltmeter which will be described in detail later, which will tell the machine whether to raise or lower the potential difference. Then the machine will take in K+ particles in order to raise the difference, which we will probably assume is the initial problem, and from then on, it will have a store of k+ to release if the difference needs to be lowered, and more room to take more k+ should the difference be higher.
We have more detail here, but time, space, and confidentiality prevent me from describing more.
Incidently, Dr. Wasser, we would like to meet with you this Wednesday sometime, preferably after the lab in the afternoon, but possibly after class, whichever is better for you.
posted by Anonymous at 4:12 PM
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